【摘要】 目的评价周剂量紫杉醇联合顺铂方案(wTP方案)作为乳腺癌术后辅助化疗方案的远期疗效和安全性。方法 20例乳腺癌术后患者均给予wTP方案化疗,21～28 d为1个周期,共4～6个周期。给药后监测毒副反应和生存情况。结果全组20例患者的5年生存率为90%。主要毒副反应为骨髓抑制、胃肠道反应,均为可逆性。结论 wTP方案作为乳腺癌术后辅助化疗方案毒副反应可耐受,患者长期生存率高。更多还原

【Abstract】 Objective To investigate the safety and long-term survival of weekly paclitaxel combined with cisplatin(wTP) as a postoperative adjuvant chemotherapy regimen in breast cancer. MethodsTwenty patients with breast cancer were treated postoperatively with wTP regimen,and repeated every 21-28 days as a cycle,and 4-6 cycles were achieved.The toxicities and survival rate were evaluated after chemotherapy. ResultsThe 5-year survival rate was 90%.The main toxicities were myelosuppression and gastrointestinal reaction,but were all reversible. ConclusionwTP regimen is safe,and the toxicities can be tolerable.The long-term survival rate is high.更多还原