【摘要】 采用研磨法,以聚乙二醇6000为载体,将竹红菌甲素制备为固体分散体,增加其在水溶液中的溶解度,提高其生物利用度。采用紫外-可见分光光度计和荧光分光光度计分别测定竹红菌甲素-聚乙二醇6000固体分散体的吸光度和荧光强度。通过正交试验设计的方差分析,得到该固体分散体的最优制备条件:药物和载体的比例(mg.mg-1)为1∶15,研磨时间为60 min,载体和去离子水的用量比例(mg.mL-1)为1∶2。对该固体分散体溶解性的影响因素进行分析,得出聚乙二醇6000及离子均会影响该固体分散体的溶解度。该固体分散体的制备方法简单,通用性强,对其他难溶药物的增溶提供参考。更多还原

【Abstract】 Objective Polyethylene glycol 6000 is the carrier material with grinding method.The solid dispersions of Hypocrellin A(HA) were prepared with Polyethylene glycol 6000 as the carrier material in grinding method to increase its solubility in water solution and improve HA bioavailability.Methods: The absorbency and fluorescence intensity of Hypocrellin A-PEG 6000 were respectively determined with UV-vis spectrophotometer and fluorescence spectrophotometer.Results: By orthogonal experimental design and analysis of variance,the better optimal process conditions were found: the proportion of drug and carrier was 1∶15(mg·mg-1),grinding time was 60min,and the ratio of the amount of carrier and distilled water was 1∶2(mg·mL-1).The factors of the solubility of the solid dispersion were analyzed,the solubility of these solid dispersions were affected by PEG 6000 and ions.Conclusion: The method of solid dispersion preparation was simple,current and the dissolution and solubility of other medications can be referenced.更多还原