【摘要】 目的:研究代谢综合征(MS)及炎症因子hsCRP水平与大肠腺瘤的相关性。方法:选取2010-01-01—2010-06-01所有接受肠镜检查的住院患者。排除既往有肠切除、息肉切除、5年内有接受肠镜检查史、恶性肿瘤史、慢性炎症性肠病史的患者,选取肠镜检查结果为大肠腺瘤及正常者为入选病例,所有研究对象均检查其FBS、TG、HDL、收缩压/舒张压、腰围、hs-CRP,进行大肠腺瘤组及正常对照组组间各临床参数的比较;对检测指标进行大肠腺瘤发病的多因素Logistic回归分析。结果:年龄≥50岁及hsCRP水平增高与大肠腺瘤发病相关(OR(95%CI)分别为1.943(1.009-3.742);18.373(3.674-91.866)),而MS及其组分与大肠腺瘤发病不相关。结论:我们的观察发现MS及其组分与大肠腺瘤发病不相关;年龄≥50岁及hsCRP水平增高增加了大肠腺瘤风险,我们需要对这些患者进行大肠镜检查以发现大肠腺瘤。更多还原

【Abstract】 Objective:To explore the relationship between metabolic syndrome,hsCRP and colorectal adenoma. Method:All cases in hospital who received colonoscopy between 2010-01-01—2010-06-01,excluded those who had a history of colonic surgery,polypectomy,colonoscopy within the previous 5 years,malignancies,chronic inflammatory bowel disease.Cases that colonoscopy showed adenoma or normal were included.The serum fasting glucose,triglyceride,high-density lipoprotein,hsCRP level and blood pressure,waist circumference were mesured in all cases.The clinical factors between group of adenoma and normal were compared.Logistic regression analysis was used to sift risk factor of colorectal adenoma. Result:Age≥50 and elevated hsCRP level were associated with colorectal adenoma(OR <95%CI> was 1.943 <1.009-3.742>;18.373<3.674-91.866>);Metabolic syndrome and its components were not associated with colorectal adenoma. Conclusion:Our findings do not support that metabolic syndrome and its components are associated colorectal adenomas.Colonoscopy is recommended when age≥50 years or hsCRP level were higher than normal.更多还原