【摘要】 目的:评价甲磺酸伊马替尼治疗晚期胃肠间质瘤的临床疗效和不良反应。方法:2006年10月至20010年10月期间经病理检查确诊的25例晚期胃肠间质瘤患者,使用甲磺酸伊马替尼400mg/日治疗。结果:25例病人均得到随访,完全缓解(CR)0例,部分缓解(PR)13例,疾病稳定(SD)8例,疾病进展(PD)4例,死亡3例。1年存活率100%,2年存活率96%。结论:甲磺酸伊马替尼治疗晚期胃肠间质瘤有较好疗效,能延长患者生命,不良反应轻微,患者能长期耐受。更多还原

【Abstract】 Objective: To evaluate the efficacy and toxicity of imatinib mesylate in the treatment of advanced gastrointestinal stromal tumors.Method:A total of 25 cases with advanced gastrointestinal stromal tumors that all proven by pathology were received imatinib mesylate at doses of 400mg/d,from Oct.2006 to Oct.2010.Result: All cases were followed up.None had complete response,13 cases achieved partial response(PR),8 cases achieved stable disease(SD) and 4 had progression disease(PD).The overall survival rates at 1 and 2 year was 100% and 96% respectively.25 patients were valuable for the toxicity assessment according to the WHO standard.Conclusion: Imatinib mesylate is a safe and efficacious drug used for the patients with advanced gastrointestinal stromal tumors.Only mild adverse reactions occur and toxicity is acceptable.更多还原