【摘要】 目的探讨凋亡抑制蛋白survivin与XIAP在甲状腺乳头状癌组织中的表达和相互关系。方法应用免疫组织化学法(S-P法)检测35例甲状腺乳头状癌,28例甲状腺腺瘤组织中survivin和XIAP的表达情况,并分析两者间的关系。结果 Survivin和XIAP在甲状腺乳头状癌组织中的阳性率分别为74.2%和94.3%,与甲状腺腺瘤比较差异有统计学意义(rs=0.57285,P<0.01)。Survivin在甲状腺乳头状癌组织中的表达与性别、年龄、肿瘤大小,结节数量无关。XIAP的表达女性高于男性(P<0.05)。结论 Survivin、XIAP在甲状腺乳头状癌中的表达增高,两者呈正相关。更多还原

【Abstract】 Objective To investigate the expression of apoptpsis inhibitor gene-survivin,XIAP in papillary thyroid carcinoma and to analyze their correlation.Methods Immunohistochemical method(SP) was used to detect the expression of survivin and XIAP in 35 cases of papillary thyroid and 28 cases of thyroid adenoma.Results The positive expression rates of survivin,XIAP were 74.2% and 94.3% respectively in papillary thyroid carcinoma,which were significantly higher than those in thyroid adenoma(P<0.01).The expression of survivin was not correlated with patients’sex,age,nodule number,tumor size in papillary thyroid carcinoma.The expression of XIAP in females was significantly higher than that in males(P<0.05).Conclusion The expression of survivin,XIAP is increased in papillary thyroid carcinoma,and there is a positive correlation between the two genes.更多还原