【摘要】 目的探讨抑癌基因p53与细胞核增殖抗原Ki-67在甲状腺乳头状癌和滤泡癌中的表达与相互关系。方法应用免疫组织化学法(sp法)检测49例甲状腺癌(包括39例乳头状癌和10例滤泡癌)、30例甲状腺腺瘤组织中p53和Ki-67的表达情况。结果 p53、Ki-67在甲状腺癌中阳性表达率分别为83.6%和69.38%,两者呈正相关(P<0.05)。两者与甲状腺腺瘤阳性表达率比较差异有统计学意义(P<0.05)。p53、Ki-67在甲状腺癌中的阳性率与性别、年龄、肿瘤大小、结节数量无关(P>0.05)。在甲状腺乳头状癌和滤泡癌中p53和Ki-67阳性率差异无统计学意义(P>0.05),但Ki-67增殖指数乳头状癌要高于滤泡癌。结论 p53与Ki-67在甲状腺癌中的表达呈正相关,Ki-67在甲状腺乳头状癌和滤泡癌中的增殖指数有差异。更多还原

【Abstract】 Objective To investigate the expression of P53,Ki-67 and their relationship in papillary thyroid carcinoma and follicular thyroid carcinoma.Methods Immunohistochemical method(SP) was used to detect the expression of P53 and Ki-67 in 49 cases of thyroid carcinoma including 39 cases of papillary thyroid carcinoma and 10 cases of follicular thyroid carcinoma,as well as 30 cases of thyroid adenoma.Results The positive expression rates of P53,Ki-67 were 83.6% and 69.38% respectively in thyroid carcinoma,which were significantly higher than those in thyroid adenoma.The positive expression rate of P53 was positively correlated with that of Ki-67 in thyroid carcinoma(P<0.05).The expressions of P53,Ki-67 were not correlated with gender,age,tumor size and nodule number(P>0.05).The positive expression rates of P53,Ki-67 were significantly different between papillary thyroid carcinoma and follicular thyroid carcinoma(P>0.05).The Ki-67 proliferation index in papillary thyroid carcinoma was higher than that of follicular thyroid carcinoma.Conclusion The expression of P53 is positively correlated with that of Ki-67 in thyroid carcinoma.The Ki-67 proliferation index is different between papillary thyroid carcinoma and follicular thyroid carcinoma.更多还原