【摘要】 以1,6-己二醇、氢溴酸、吡啶等为原料,通过溴化、置换、合成、加成、水解等反应合成了1,8-辛二醇。经过优化,得到威廉逊合成的最佳反应条件为甲醇钠与1-溴-6-氯己烷摩尔比为1∶1.25,催化剂的用量为2.0%(占1-溴-6-氯己烷物质的量的比例),反应温度为60℃,反应时间为6 h,环氧乙烷加成反应的温度以0℃左右为宜,在最佳反应条件下,总产率可达70.5%。更多还原

【Abstract】 Using 1,6-hexanediol,hydobromic acid and pyridine as raw material,1,8-octanediol was synthesized through steps including bromide,replacement,systhesic,addition and hydrolyzation etc.The optimized reaction conditions of Williamson Synthesis were,molar ratio of sodium methoxide and 1-pentabromo-6-chlorohexane,1∶1.25;Catalyst dosage,2.0% of amount of 1-pentabromo-6-chlorohexane;Reaction temperature,60 ℃;Reaction time,6 h.The addition temperature of epoxy ethane should be around 0 ℃.The total yield of 1,8-octandiol could reach up to 70.5% under the best reacting conditions.更多还原