【摘要】 目的探讨唾液是否为乙型肝炎病毒传播的途径之一,为乙型肝炎病毒经唾液传播提供临床依据。方法采用时间分辨荧光免疫分析法检测免疫学指标,实时荧光定量PCR法检测乙肝患者血清、唾液HBVDNA含量。结果 119例乙肝患者血清、唾液HBVDNA的阳性率分别为91.6%(109例)、71.4%(85例)。乙肝患者唾液HBVDNA的阳性率与血清HBVDNA的阳性率之间差异有统计学意义(P<0.01),乙肝患者唾液HBVDNA含量与血清HBVDNA含量呈显著正相关(r=0.83)。结论乙型肝炎病毒可通过唾液传播。更多还原

【Abstract】 Objective To investigate whether saliva is one of the important pathways for the transmission of hepatitis B virus(HBV),and to provide clinical evidences the spreading of HBV through saliva.Methods Immunological indicators were determined with time-resolved fluoroimmunoassay(TR-FIA),and the contents of HBV DNA in serum and saliva were determined with real-time polymerase chain reaction(FQ-RT-PCR).Results In 119 cases of hepatitis B,the positive rate of HBV DNA in serum and saliva was 91.6%(n=109) and 71.4%(n=85),respectively,which showed a statistically significant difference(P<0.01).A positive correlation was found between the content of HBV DNA in serum and that in saliva(r=0.83).Conclusion This study provides clinical evidences for the transmission of HBV through saliva.更多还原