【摘要】 目的观察雷帕霉素(Rapamycin)体外对肝癌HepG-2细胞侵袭能力的影响。方法用不同浓度的雷帕霉素作用于体外培养的HepG-2细胞,应用Matrigel胶模拟基质检测细胞侵袭能力。结果雷帕霉素能显著降低肿瘤细胞的侵袭能力,随剂量增高降低越明显。各药物处理组与阴性对照组相比差异具有统计学意义(P<0.05)。结论雷帕霉素能有效地降低肝癌细胞HepG-2的侵袭能力。更多还原

【Abstract】 Objective To investigate the effect of cell invasion ability induced by rapamycin on human hepatocellular carcinoma HepG-2 cells.Methods HepG-2 cells in vitro were given different concentrations of rapamycin,and the invasion ability of HepG-2 cells was observed by Matrigel.Results Rapamycin could inhibit the invasion ability of HepG-2 cells,and and the inhibit presented dose-dependent relationship.There was significantly different between rapamycin given groups and control group.Conclusion Rapamycin significantly inhibits the invasion ability of HepG-2 cells.更多还原