【摘要】 目的:利用弥散张量成像量化分析多发性硬化患者颅脑常规磁共振看似正常的脑灰、白质是否存在隐匿性损伤。方法:本院36例随访确诊多发性硬化患者及20例性别、年龄与之匹配的健康对照组,行常规磁共振及弥散张量成像,对不同解剖部位的表观弥散系数（ADC）、各项异性（FA）值进行对比分析,包括常规T₂WI像看似正常脑皮层（NACGM）、深部灰质核团（NADGM）及看似正常脑白质区（NAWM）,并分析这些指标与扩展残疾状态量表（EDSS）评分的相关性。结果:MS患者NACGM区的ADC值增加,FA值下降,NADGM区中丘脑ADC、FA值改变差异有统计学意义,NAWM区呈现弥漫性ADC值增加,FA值下降。枕叶白质FA值与EDSS评分呈负相关,丘脑FA值与病程负相关。结论:常规MRI表现正常的脑灰、白质区域存在微结构破坏,DTI可以作为反映MS微观病理改变的敏感指标。更多还原

【Abstract】 Objective:The purpose is using diffusion tensor imaging quantitative analysis of multiple sclerosis patients whether there is delitescence damage in normal-appearing gray matter and white matter. Methods:There are 36 cases were followed up diagnosed MS and 20 sex and age matched healthy control group, using routine MRI imaging and DTI imaging,the different anatomical parts of the apparent diffusion coefficient and the fractional anisotropy were measured between the two groups,including the analysis of conventional T2WI as seemingly normal appearing cortical gray matter(NACGM ),deep gray matter nuclei(NADCM ) and the performance of normal white matter(NAWM ),and analysis of these indicators and Expanded Disability Status Scale(EDSS) score of relevance.Results:MS patients’ NACGM area is increased ADC,FA values decreased. NADGM area only had significant changes of FA values in thalamus,NAWM areas showed diffuse increase in ADC values and FA values decreased.FA values of Occipital white matter were negatively correlated with the EDSS score.The FA value of thalamus were negatively correlated with the course of disease.NADGM area only had significant changes of FA values in thalamus,NAWM areas showed diffuse increase in ADC values and FA values decreased.FA values of Occipital white matter were negatively correlated with the EDSS score.The FA value of thalamus were negatively correlated with the course of disease.NADGM area only had significant changes of FA values in thalamus,NAWM areas showed diffuse increase in ADC values and FA values decreased.FA values of Occipital white matter were negatively correlated with the EDSS score.The FA value of thalamus were negatively correlated with the course of disease.Conclusion:Conventional MRI showed the existence of microstructural damage in normal-appearing brain gray and white matter.DTI can be used as sensitiwity indicators that reflect the micro-pathological changes of MS patients.更多还原