【摘要】 在介绍中红外无创血糖研究进展的基础上,实验探讨了组织液渗透到手指皮肤表面时,角质层对血糖测量的影响。加入角质层干扰信息前,用偏最小二乘法(PLSR)建立了模拟组织液中葡萄糖定标模型,其内部交叉验证均方差(RMSECV)为9.6 mg/dL;加入三个志愿者手指皮肤吸收的干扰信息后,所得三个模型的RMSECV分别为17.4,16.3和17.1 mg/dL。结果表明,当组织液渗透到手指皮肤表面时,不同志愿者的角质层对定标模型的影响程度大致相同;计入角质层的干扰,中红外光谱无创血糖的检测精度有望达到18 mg/dL。更多还原

【Abstract】 The progress of non-invasive blood glucose determination based on mid-infrared spectroscopy is introduced firstly.After this,the effect of stratum corneum(SC) on blood glucose determination is studied by experiment while interstitial fluid(ISF) is collected on the skin surface.Using the spectra of simulated ISF,partial least square regression(PLSR) calibration model of glucose determination is estabished,and the value of root mean squares error of cross validation(RMSECV) is 9.6 mg/dL.While including the interference of stratum corneum from three volenteers individually,three RMSECV are obtained,and they are 17.4,16.3 and 17.1 mg/dL,respectively.The results show that the effects of SC from different volenteers are the same nearly;including the interference of SC,the accuracy of the non-invasive blood glucose determination based on attenuated total reflection mid-infrared spectroscopy can reach 18 mg/dL.更多还原