【摘要】 以ESIS(环氧化苯乙烯-异戊二烯-苯乙烯嵌段共聚物)为基体树脂、环氧大豆油为增塑剂和高度氢化松香为增黏树脂,制备出一种ESIS型HMPSA(热熔压敏胶)。以ESIS、增塑剂和增黏树脂用量作为试验因素,HMPSA的初粘力、剥离强度和持粘力作为考核指标,采用正交试验和载药量试验法优选出制备中药贴片用ESIS型HMPSA的最佳配方。结果表明:当m(ESIS)∶m(环氧大豆油)∶m(高度氢化松香)∶m(抗氧剂1010)=100∶80∶100∶1.4时,ESIS型HMPSA的综合性能满足中药贴片的使用要求,并且其最大载药量(34%)和水蒸气透过率[1.297 g/(m2.d)]均高于同类产品(医用SIS型压敏胶和传统天然橡胶膏)。更多还原

【Abstract】 With ESIS(epoxidized styrene-isoprene-styrene block copolymer) as matrix resin,epoxy soybean oil as plasticizer,and highly hydrogenated rosin as tackifying resin,an ESIS-HMPSA(hot melt pressure-sensitive adhesive) was prepared.With ESIS,plasticizer and tackifying resin contents as experiment factors,the initial tack,peeling strength and holding tack of HMPSA as evaluating index,the optimal formula of preparing ESIS-HMPSA for Chinese traditional medicine-PSA patch was preferred by orthogonal experiment and drug-loading contents experiment methods.The results showed that the combination property of ESIS-HMPSA could meet the application requirement of Chinese traditional medicine-PSA patch because the maximum drug-loading contents(34%) and water vapor transmission[1.297g/(m2·d)] of ESIS-HMPSA were more than those of the congeneric products(such as the medical SIS type pressure-sensitive adhesive sheet and traditional natural rubber sheet) when the mass ratios of m(ESIS)∶m(epoxy soybean oil)∶m(highly hydrogenated rosin)∶m(antioxidant 1010) were 100∶80∶100∶1.4.更多还原