【摘要】 以L-丙氨酸、3-苯甲酰基丙烯酸乙酯等为原料,通过Michael加成反应,制得中间体N-((S)-1-乙氧羰基-3-氧代-3-苯丙基)-L-丙氨酸,进而在钯-碳催化下进行氢化反应,得到目标产物N-((S)-1-乙氧羰基-3-苯丙基)-L-丙氨酸(ECPPA),收率90%;用红外、核磁共振、元素分析等方法对其结构进行表征。更多还原

【Abstract】 The intermediateN-((S)-1-ethoxycarbonyl-3-oxo-3-phenylpropyl)-L-alanine(ECOPPA)was prepared by Michael addition with L-alanine and 3-Benzoylacrylic acid ethyl ester as primary materials.The title compounds N-((S)-1-ethoxycarbonyl-3-phenylpropyl)-L-alanine(ECPPA)was obtained by ECOPPA reacted with Pd-C catalyst in a solvent by hydrogenation with the yield of 90%.Their structures were characterized by IR,NMR andelemental analysis.更多还原