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脑梗死神经血管单元的病变机制与治疗策略
Pathological mechanism and therapeutic strategy of neurovascular unit after cerebral infarction
【摘要】 神经血管单元是一个由神经元、血脑屏障、小胶质细胞及细胞外基质构成的整体,与脑梗死的发生发展关系密切,可能是治疗脑梗死的潜在靶点。本文介绍了神经血管单元的概念、组成及脑梗死后神经血管单元的病变机制及治疗策略,为相关脑血管疾病治疗药物的研究提供了新思路。
【Abstract】 Neurovascular unit(NVU) is composed of neuron,blood brain barrier,microgial cells and extracellular matrix,which is related closely with the occurence and development of cerebral infarction,probably provides a potential target for treatment of cerebral infarction and its complication.This article reviews the conception and the composition of NVU,aslo introduces the pathological mechanism and therapeutic methods of NVU after cerebral infarction,aiming to provide some new ideas in the treatment of cerebrovascular disease.
【基金】 国家自然基金面上项目(30973959,20962012);中央高校基本科研业务费专项资金(中央民族大学自主科研计划项目0910KYXJ12);中央民族大学211工程三期创新人才培养项目(0212110309100435)
- 【文献出处】 国际药学研究杂志 ,Journal of International Pharmaceutical Research , 编辑部邮箱 ,2011年02期
- 【分类号】R743.3
- 【被引频次】17
- 【下载频次】716