【摘要】 目的:探讨阿托伐他汀对伴有高胆固醇血症的代谢综合征患者血糖的影响。方法:将129例伴高胆固醇血症的代谢综合征患者,分为阿托伐他汀10mg组(n=44)、20mg组(n=42)和40mg组(n=43),10周后比较治疗前后血清学指标的变化。结果:与基线水平相比,阿托伐他汀10、20和40mg组均能显著降低总胆固醇、LDL-C(P均<0.05),但是明显升高胰岛素抵抗指数和糖化血红蛋白水平(P均<0.05)。其中,40mg组较20mg组胰岛素抵抗指数进一步增加(P<0.001)。20mg和40mg组空腹胰岛素水平升高;但仅40mg组血糖升高(P<0.05)。结论:在伴有高胆固醇血症的代谢综合征患者中采用阿托伐他汀治疗,能够显著改善血脂代谢,但是同时会导致胰岛素抵抗水平的升高,表现为糖代谢受损。更多还原

【Abstract】 Objective:To investigate whether atorvastatin exerts an effect on glucose metabolism in metabolic syndrome patients with hypercholesterolemia.Methods:A randomized prospective study was conducted in 44,42,and 43 patients given daily atorvastatin 10,20,and 40 mg,respectively,during a 10-week treatment period.Results:Atorvastatin 10,20,and 40 mg significantly reduced total cholesterol and LDL cholesterol(P<0.05) after 10 weeks compared with baseline.Atorvastatin 20 and 40 mg significantly increased fasting plasma insulin(P<0.01).All treatment groups experienced significantly elevated insulin resistance and glycated hemoglobin levels(P<0.05) when compared with baseline.Atorvastatin 40 mg further increased insulin resistance(P<0.001) compared with atorvastatin 20 mg,however,only Atorvastatin 40 mg resulted in increased blood glucose(P<0.05).Conclusion:Despite beneficial effects on lipid profiles,atorvastatin treatment resulted in significant increases in insulin resistance and glycated hemoglobin levels consistent with impaired blood glucose in metabolic syndrome patients with hypercholesterolemia.更多还原