【摘要】 目的探讨流感病毒(IV)感染与急性心肌梗死(AMI)的关系。方法采用ELISA法检测74例AMI患者和77例对照组IV-A、IV-B抗体及白细胞介素-18(IL-18)、超敏C反应蛋白(hsCRP)的水平,并对冠心病危险因素进行调查。结果 AMI组IV-AIgG、IV-BIgG阳性率及IL-18、hsCRP水平均显著高于对照组,差异有统计学意义(P<0.01),且IgG水平与IL-18、hsCRP呈正相关。校正冠心病危险因素前后,IV-A和IV-BIgG阳性均与AMI有相关性。结论 IV感染可能激发或加重冠状动脉内炎性反应,IL-18和hsCRP参与AMI的病理过程。更多还原

【Abstract】 Objective To study the association between influenza virus infection and acute myocardial infarction (AMI).Methods 74 patients with AMI(AMI group),77 healthy controls were enrolled(control group). For all subjects,antibodies specific for IV-A and IV-B,levels of interleukin-18 (IL-18) and hypersensitive C-reactive protein (hsCRP) were measured by ELISA. Meanwhile,the risk factors of coronary heart disease were investigated.Results The positive rates of antibodies specific for IV-A and IV-B IgG,and levels of IL-8 and hsCRP in AMI group were all significantly higher than those in control group. For AMI group,there was positive correlation between level of IgG and levels of IL-8 and hsCRP. After the adjustment of cardiovascular risk factors,IV-A and IV-B IgG antibodies were both correlated with AMI.Conclusion There could be significant correlation between influenza virus infection and AMI.IL-18 and hsCRP may be involved in the pathogenesis of atherosclerosis and myocardial infarction by inducing and accelerating coronary artery inflammation.更多还原