【摘要】 目的了解血红蛋白(Hb)及血细胞常规检测对儿童珠蛋白生成障碍性贫血(THal)筛查的价值。方法对2171例7岁以下儿童进行Hb电泳和血细胞常规检测,并进行统计学分析。结果各检测项目单项检测用于诊断THal时,红细胞平均体积(MCV)和红细胞平均血红蛋白量(MCH)的灵敏度较高,红细胞分布宽度-变异系数(RDW-CV)和Hb电泳的特异度和正确率较高;联合检测各项指标时,平行检测及系列检测诊断β-THal的正确率优于α-THal。结论建议在同等条件下以MCH筛查THal。降低MCV及MCH的临界值可提高诊断特异度和正确率。联合检测RDW-CV与MCV或MCH可提高THal筛查正确率,并有助于THal和缺铁性贫血的鉴别诊断。更多还原

【Abstract】 Objective To explore the value of hemoglobin(Hb)and the index of routine blood detection for the screening of thalassemia in children.Methods 2 171 cases of children under 7 years old were enrolled and detected for Hb electrophoresis and routine blood detection.All data were statistically analyzed.Results Mean corpuscular volume(MCV) and mean corpuscular hemoglobin(MCH)were the most sensitive,and RBC distribution width-coefficient of variation(RDW-CV) and Hb electrophoresis were the most specific and accurate there are specificity and accurate for the diagnosis of thalassemia,when being analyzed separately.When the indexes were associate analyzed,the accuracy of parallel and serial detection in the diagnosis of β-thalassemia was better than that of α-thalassemia.Conclusion It could be suggested that MCH could be used for the screening of thalassemia under the same conditions.The diagnostic specificity and accuracy could be improved by reducing the cut-off value of RDW and MCH joint screening of thalassemia.Combined detection of RDW-CV and MCV or MCH could further improve the diagnostic accuracy and the differential diagnosis of thalassemia and iron deficiency anemia.更多还原