【摘要】 目的探讨糖化血红蛋白(HbA1c)对糖尿病(DM)诊断的临床价值。方法以143例健康人、82例空腹血糖受损(IFG)患者和340例DM患者进行口服糖耐量试验(OGTT),葡萄糖氧化酶电极法测定血糖,免疫透射比浊法测定HbA1c,对结果进行分析。结果从健康组、IFG组到DM组,HbA1c水平逐渐增高,各组间比较差异均有统计学意义(P<0.05),以HbA1c≥6.5%或HbA1c≥7.0%作为DM诊断临界值,其诊断灵敏度分别为99.18%和97.33%,诊断特异度分别为94.45%和99.97%,均优于以空腹血糖(FPG)大于或等于7 mmol/L作为诊断临界值的诊断灵敏度(76.43%)和诊断特异度(89.82%)。结论 HbA1c具有比FPG更高的DM诊断灵敏度和诊断特异度;比OGTT更为简便快速,有利于DM的早期诊断,适合作为DM诊断指标而广泛应用。更多还原

【Abstract】 Objective To investigate the diagnostic value of glycosylated hemoglobin A1c(HbA1c)for diabetes mellitus(DM).Methods Oral glucose tolerance test(OGTT)was performed among 143 case of healthy controls,82 patients with impaired fast glucose(IFG)and 340 patients with DM.Glucose oxidase electrode and immunoturbidimetry was used to measure the level of blood glucose and HbA1c respectively.Results The HbA1c level of the DM group was significantly higher than the control group and the IFG group(P<0.05),and that of the IFG group was also significantly higher than the control group(P<0.05).The diagnostic sensitivity and specificity of HbA1c for DM,taking 6.5% or 7.0% as the cut-off point,were all higher than those of fasting blood glucose(FPG),taking 7mmol/L as cut-off point.Conclusion For the diagnosis of DM,HbA1c was more sensitive and specific than FPG,and more simple and fast,compared with OGTT.The detection of HbA1c was important for early diagnosis of DM.更多还原