【摘要】 目的检测黑色素瘤抗原A3(MAGE-A3)在原发性肺癌组织中的表达情况,并探讨其临床意义。方法应用间接酶免疫组化技术检测MAGE-A3抗原在48例肺癌组织中的表达情况,并分析其与肺癌分型和淋巴结转移的关系。结果 48例肺癌患者中有29例(60.4%)为MAGE-A3抗原表达阳性,19例(39.6%)为MAGE-A3抗原表达阴性;肺腺癌、肺鳞癌、肺腺鳞癌和小细胞肺癌的阳性率分别为80.0%、31.3%、75.0%和33.3%;肺腺癌组的阳性率显著高于肺鳞癌组(χ2=9.744,P<0.05),淋巴结转移组和非淋巴结转移组的阳性率差异无统计学意义(χ2=0.001,P>0.05)。结论 MAGE-A3抗原在肺癌组织中有较高的表达率,肺腺癌组MAGE-A3的表达阳性率显著高于肺鳞癌组,肺癌淋巴结转移组和非淋巴结转移组的阳性率差异无统计学意义。更多还原

【Abstract】 Objective To detect the expression of MAGE-A3 in primary lung carcinoma tissues and explore its clinical significance.Methods Indirect enzyme immunohistochemical method was performed to detect the expression of MAGE-A3 in 48 cases of primary lung cancer tissues.The correlation between MAGE-A3 and the histological types of primary lung cancer and lymph node metastasis.Results Among the 48 cases of patients with lung cancer,29(60.4%) cases were positive with MAGE-A3 and 19(39.6%) were negative.The positive rates of MAGE-A3 in lung adenocarcinoma(LA),lung squamous cell carcinoma(LSqCa),lung adenosquamous carcinoma(LASCa) and small cell lung cancer(SCLC) were 80.0%,31.3%,75.0% and 33.3%.The positive rate of MAGE-A3 in LA group was higher than that of LSqCa group(χ2=9.744,P<0.05),but there was no statistical difference of it between lymph node metastasis group and non-lymph node metastasis group(χ2=0.001,P>0.05).Conclusion The expression of MAGE-A3 was more frequent in lung carcinomas,especially in LA,the positive rate of which was higher than LSqCa,while the expression of MAGE-A3 was not significantly associated with lymph node metastasis.更多还原