【摘要】 目的探讨液基细胞学技术(TCT)与高危型人乳头瘤病毒(HPV)检测在宫颈病变中的诊断价值。方法对2008年1~6月在妇科门诊就诊的396例宫颈病变的患者进行TCT、高危型HPV DNA检测,以病理组织学诊断结果为金标准。结果将ASCUS以上的病变作为细胞学阳性诊断,其阳性率为21.71%(86/396),组织学将CINⅠ以上病变作为阳性诊断,阳性率为17.42%(69/396),两者比较差异无统计学意义(P>0.05);高危型HPV检测396例,阳性率为19.44%(77/396),其慢性炎症、CINⅠ、CINⅡ~Ⅲ和SCC的HPV感染率分别为7.05%、49.28%、71.43%、100.00%。结论 TCT联合HPV DNA检测可提高宫颈疾病筛查的敏感度和阴性预测值。更多还原

【Abstract】 Objective To study the diagnostic value of thinprep cytologic test with high risk HPV DNA testing in cervical lesions.Methods 396 cases with cervical lesions were tested with TCT and high risk HPV DNA test,the histopathological diagnosis was as the gold standard.Results More than ASCUS changes as a positive diagnosis of cytology,the positive rate was 21.71%(86/396);more than CINⅠ disease as a positive diagnosis,the rate was 17.42%(69/396),their difference was not significant(P>0.05).In high risk HPV DNA test,the rate of infection was 19.44%(77/396).HPV infection rate of chronic inflammation,CINⅠ,CINⅡ-Ⅲ and SCC were 7.05%,49.28%,71.43%,100.00%.Conclusion The combination of TCT and high risk HPV DNA test increases the sensitivity and negative predictive value of screening.更多还原