【摘要】 目的研究血浆纤维蛋白降解产物(FDP)和D-二聚体测定对肝炎及肝硬化的临床意义,并探讨肝病凝血功能紊乱的机制。方法分别测定急性肝炎患者35例、慢性肝炎患者38例、肝硬化患者33例和40例健康者的血浆FDP及D-二聚体含量。结果肝硬化组与各组间血浆FDP含量差异有统计学意义(P<0.01);慢性肝炎组与急性肝炎组血浆D-二聚体含量差异有统计学意义(P<0.05);其余各组间血浆D-二聚体含量差异有统计学意义(P<0.01)。FDP和D-二聚体含量从急性肝炎、慢性肝炎、肝硬化依次递增。结论血浆D-二聚体和FDP测定可作为判断肝病严重程度的有效指标,对病情的诊断和预后判断有重要的指导价值。更多还原

【Abstract】 Objective To investigate the clinical significance of plasma fibrin degradation products(FDP) and D-dimer in hepatitis and liver cirrhosis,and the mechanism of coagulation disorders in patients with liver disease.Methods Plasma FDP and D-dimer were detected in 35 cases of patients with acute hepatitis,38 cases with chronic hepatitis,33 cases with liver cirrhosis and 40 healthy controls.Results There were statistical differences of FDP between liver cirrhosis group and the other groups(P<0.01).There were also statistical differences of D-dimer between chronic hepatitis group and acute hepatitis group(P<0.05) and between the other groups(P<0.01).The concentrations of plasma FDP and D-dimer were in ascending order from acute hepatitis,chronic hepatitis,to liver cirrhosis.Conclusion Plasma D-dimer and FDP could be effective indicators for the judgement of the severity of liver diseases and have certain instructive value in the diagnosis and prognosis of diseases.更多还原