【摘要】 目的探讨白介素-1β及其受体拮抗剂在绝经后女性骨代谢中的作用。方法选择绝经后女性128名,绝经前女性47名。用酶联免疫法测定受试者血清白介素-1β（IL-1β）、IL-1受体拮抗剂（IL-1Ra）、血清骨钙素（BGP）、尿I型胶原C末端肽（CTX）水平。用放射免疫法测定总雌二醇（E2）。结果绝经后女性组受试者L_2-4、股骨颈、大转子的骨密度、E2、IL-1Ra/IL-1β比值和BGP较绝经前女性低,但CTX较高。L_2-4、股骨颈骨密度、BGP与IL-1Ra/IL-1β呈正相关（r=0.709、r=0.801、r=0.729,P=0.023、P=0.021、P=0.005）。L_2-4、股骨颈、大转子骨密度与IL-1β负相关（r=-0.855、r=-0.921、r=-0.725,P=0.002;P=0.005、P=0.024）。CTX与IL-1Ra/IL-1β负相关、与IL-1β正相关（r=-0.774,P=0.037;r=-901,P=0.036）。IL-1Ra与IL-1β正相关（r=0.981,P=0.005）。L_2-4、大转子骨密度、BGP与E2正相关（r=0.664、r=0.700、r=0.621,P=0.012、P=0.003、P=0.009）。IL-1Ra、IL-1Ra/IL-1β与E2正相关（r=0.874,P=0.004;r=0.802,P=0.024）。结论绝经后女性骨代谢处于高分解、低合成的负平衡状态,性激素水平降低影响IL-1Ra与IL-1β的平衡可能起重要作用。更多还原

【Abstract】 Objective To test the roles of circulating cytokine,interleukin-1β（IL-1β）,interleukin-1 receptor antagonist（IL-1Ra） and some bone biochemical markers in bone metabolism.Methods Serum IL-1β,IL-1Ra, bone Gla protein（BGP）,C-terminal telopeptide of type I collagen（CTX） were measured by ELISA and estradiol（E2） were measured by RIA in 128 postmenopausal women and 47 premenopausal women.Results The postmenopausal women had lower bone mineral density（BMD） in lumbar spine 2-4(L_2-4),femoral neck（FN） and greater trochanter, IL-1Ra/IL-1βratio,serum levels of E2 and BGP,but with higher urine level of CTX.BMD in L_2-4 and other sites and BGP level were positively but CTX was negatively correlated with IL-1Ra/IL-1βratio.E2 had positive relationship with BMD in some sites and BGP.Further more,IL-IRa and IL-1Ra/IL-1βratio were significant correlations with level of E2 （r = 0.874.P = 0.004;r = 0.802,P = 0.024 respectively）.Conclusion The postmenopausal women have lower BMD,bone formation marker BGP and higher bone resorption marker CTX,a condition with negative bone turnover.As a result of decrease of gonad hormones,the imbalance of IL-1 Ra and IL-1βmay play an important role in bone metabolism in postmenopausal women.更多还原