【摘要】 采用紫外光谱,荧光光谱研究了6种新型的具有抗菌活性的稀土-异亮氨酸-邻菲咯啉三元配合物[RE(Ile)3PhenCl3.4H2O,RE=La、Eu、Sm、Nd、Y、Yb]与小牛胸腺(CT-DNA)的作用机理,研究表明,三元配合物与CT-DNA的作用方式为嵌入作用。这一研究结果为稀土配合物在农牧业作为动植物的广谱抗菌剂方面的应用提供了理论依据,有利于进一步研究稀土抗菌剂的药学机理,进而筛选出高疗效的稀土药物。更多还原

【Abstract】 The action mechanism between the calf thymus deoxyribonucleic acid(CT-DNA) and six novel rare earth ternary complexes [RE(Ile)3PhenCl3·4H2O,RE=La,Eu,Sm,Nd,Y,Yb] with strong antibacterial activities were investigated by UV and fluorescence spectroscopy.The interactions of ternary complexes with CT-DNA were embedded mode.The promoting results provide theoretical basis in the application of the rare earth complexes as the broad-spectrum antibacterial agents for animals and plants,which is very beneficial to research further the drug mechanism of rare earth antibacterial agents,and to screen out higher-curative effect drugs futher.更多还原