【摘要】 目的探讨全髋与全膝关节置换术后应用低分子肝素(LMWH)预防深静脉血栓(DVT)的时机。方法 158例全髋与全膝关节置换者中髋关节置换(THA)81例、全膝关节置换(TKA)77例。观察术后不同时机使用LMWH对术后引流量、DVT发生率的影响。结果 THA术后开始使用LMWH组引流量与术后72 h组差异具有统计学意义(P=0.000),而TKA术后组与术后72 h组差异无统计学意义(P=0.552)。在THA和TKA中,术后组与术后72 h组DVT发生率差异均有统计学意义(P=0.000)。结论 THA术后LMWH的最佳应用时机是术后72 h,但术后即应用LMWH则是TKA术后预防DVT的最佳时机。更多还原

【Abstract】 Objective To explore the effect of low molecular weight heparin(LMWH) used at different time postoperatively in total hip arthroplasty(THA) and total knee arthroplasty(TKA).Methods One hundred and fifty eight patients underwent resurfacing arthroplasy,including THA 81 patients and TKA 77 patients.The effect of LMWH used at different time after operation on the amount of blood loss and the DVT incidence rates were observed.Results In THA group,there were significant differences between the postoperative and 72 hours later postoperative LMWH using groups in the amount of lead flow,while in the TKA group there were no significant difference between the postoperative and 72 hours later postoperative LMWH using groups in the amount of lead flow.In THA and TKA groups,there were significant differences between the postoperative and 72 hours later postoperative LMWH using groups in the incidence rate of DVT.Conclusion LMWH used 72 hours later postoperatively can obviously decrease the incidence rate of DVT in THA,but in TKA the optimal time for using LMWH probably is immediately after operation.更多还原