【摘要】 目的 Ezrin是细胞膜与细胞骨架连接蛋白,参与肿瘤细胞的侵袭和转移。本研究通过检测p-ezrin和p-p38在乳腺浸润性导管癌中的表达情况,探讨其与乳腺癌转移的关系和意义。方法采用免疫组织化学SP法检测80例乳腺浸润性导管癌组织切片中p-ezrin和p-p38的表达。结果 p-ezrin在33例无转移的癌组织中7例异常高表达(21.2%),47例有转移的癌组织中27例异常高表达(57.4%)。p-p38在无转移的癌组织中15例异常高表达(45.5%),而在有转移的癌组织中34例异常高表达(72.3%)。p-ezrin异常表达与p-p38异常表达正相关性(r=0.269,P=0.016)。结论 p-ezrin和p-p38与乳腺导管癌的浸润和转移密切相关,可以作为预测浸润性乳腺导管癌淋巴结转移的重要肿瘤标志物。更多还原

【Abstract】 Objective To examine the expressions of p-ezrin and p-p38 in breast invasive ductal carcinomas(IDC),and analyze its relationship and significant with the metastasis of breast cancer.Methods The expressions of p-ezrin and p-p38 were examined using immunohistochemistry S-P method in 80 IDC tissues.Results The abnormal high expression of p-ezrin was found in 7 cases of 33 IDC tissues without metastasis(21.2%) and in 27 cases of 47 IDC tissues with metastasis(57.4%).The abnormal high expression of p-p38 was found in 15 cases of IDC without metastasis(45.5%) and in 34 cases of IDC with metastasis(72.3%).The abnormal expressions of p-ezrin and p-p38 were positively correlated with each other(r = 0.269,P = 0.016).Conclusion p-ezrin and p-p38 are correlate with the invasion and metastasis of IDCs and might be important markers of lymph node metastasis of IDCs.更多还原