【摘要】 目的探讨同型半胱氨酸和蛋氨酸合成酶(MS)A2756G基因多态性与颅内动脉瘤的关系。方法运用多聚酶链反应技术和化学发光法检测76例颅内动脉瘤及77例正常人MS A2756G基因多态性。结果颅内动脉瘤组的MSD919G DG基因型频率较正常对照高(P<0.01),患颅内动脉瘤的风险是对照组的6.35倍。两组等位基因频率差异无统计学意义(P>0 05)。结论 MS D9l9G的DG基因型与颅内动脉瘤明显相关,高同型半胱氨酸血症与颅内动脉瘤病发生有一定关系。更多还原

【Abstract】 Objective To explore relationship of polymorphism of methionine synthase gene(MS) and plasma homocysteine level with intracranial aneurysm.Methods The genotyes of MS were determined by PCR-based assay and their plasma homocysteine levels were determined in 76 patients with intracranial aneurysm and 77 healthy controls.Results Aneurysm group MS D919G DG frequency was higher than normal genotype(P < 0.01),the risk of intracranial aneurysm patients was 6.35 times the control group.Allele frequency of the two groups was no significant difference(P > 0.05).Conclusions The methionine synthase genotype may be independent risk factors for intracranial aneurysm and hyperhomocysteinemia may be independent risk factors for Intracranial aneurysm.更多还原