The three dimensional structure of human α1A-Adrenoceptors was modeled and refined using homology modeling and molecular dynamics simulation.The model was assessed by PROCHECK,PROSA and WHAT-IF methods,which confirmed that the obtained model was reliable.An agonist norepinephrine and an antagonist silodosin were docked into the refined structure by the molecular docking programs Flexidock.The results showed that the two ligands shared the similar binding cavity,which interact with the residues Asp106,Ser188...
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