【摘要】 比较了四种选择性β2受体手性药物氯丙那林、沙丁胺醇、克伦特罗以及丙卡特罗在Whelk-O1、DNB-PG、DNB-Leucine和SH-1等四种刷型酰胺手性固定相上的对映体直接拆分行为,考察了被分离化合物分子结构、固定相分子结构等因素对对映体分离选择性的影响,对药物与固定相分子的手性识别机理进行了初步探讨,给出了药物分子与手性固定相分子间的相互作用模型。研究结果表明,在给定色谱条件下,沙丁胺醇对映体在四种固定相上均未能分离,氯丙那林仅在Whelk-O1上有弱的分离,克伦特罗的对映体仅在SH-1上未分离,丙卡特罗的部分对映体在四种固定相上均达到了一定程度的拆分,最大分离因子达1.58。更多还原

【Abstract】 Four β2 acceptor drugs-cloprenaline,albuterol,procaterol and clenbuterol have been separated on four brush type acylamide chiral stationary phases(CSPs),Whelk-O1,DNB-PG,DNB-Leucine and SH-1 by high performance liquid chromatography.The factors that effect enantioseparation,such as the stractures of drugs and CSPs,have been investigated,and the chiral recognition mechanism has also been briefly discussed based on the molecular interaction model between the drugs and CSPs.Chiral separation of the drugs except Albuterol on four CSPs has been achieved with the maximum separation factor of 1.58.The result shown that the hydrogen bond between the enantiomers and CSPs was the main interaction in the chiral recognition process,but the π-π electron transfer interaction was still the prerequisite for the selective separation.更多还原