【摘要】 目的:探讨了慢性肾炎患者在输注红细胞前后血清铁蛋白(SF)、血管内皮生长因子(VEGF)和肝细胞生长因子(HGF)水平的变化及意义。方法:应用放射免疫分析和酶联法对30例慢性肾炎患者进行了输注红细胞前后SF、血清VEGF和HGF检测,并与35名正常健康人作比较。结果:慢性肾炎患者在输注红细胞前SF水平非常显著地低于正常人组(P<0.010),而VEGF和HGF水平又非常显著地高于正常人组(P<0.01),经2周输注红细胞后则与正常人组比较无显著性差异(P>0.05)。结论:检测慢性肾炎输注红细胞治疗前后SF、血清VEGF和HGF水平的变化对其病情的发展和预后判断均具有重要的临床价值。更多还原

【Abstract】 Objective To observe the changes of serum SF,VEGF and HGF levels and after transfusion of red blood cells(RBC) in patients with chronic nephritis.Methods Serum SF(with RIA) and serum VEGF,HGF(with ELISA) levels were measured in 30 patients with chronic nephritis both before and after a course of transfusion of RBC and 35 controls.Results Before transfusion the serum SF levels in the patients were significantly lower than those in controls(P<0.01),while the serum VEGF,HGF levels were prominently higher(P<0.01),after a course of 2 weeks transfusion of RBC the serum SF,VEGF and HGF levels in the patients were no significant difference from those in controls(P>0.05).Conclusion Determination of serum SF,VEGF and HGF levels were clinically useful for the progress,prognosis and judgement of chronic nephritis.更多还原