【摘要】 目的:探讨冠心病(CHD)患者血浆N末端脑钠肽原(NT-proBNP)与大内皮素-1(B ig ET-1)水平的变化及其与心功能的关系。方法:采用酶联免疫吸附试验双抗体夹心法对136例CHD患者及55例健康对照者进行血浆NT-proBNP和B ig ET-1测定,同时以彩色多普勒超声心电动仪测定CHD患者左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF),并与血浆NT-proBNP和B ig ET-1水平进行相关性分析。结果:CHD患者血浆NT-proBNP和B ig ET-1水平均明显高于健康对照者(P<0.01),且不同心功能患者之间的血浆NT-proBNP和B ig ET-1含量亦存在显著性差异(P<0.01);CHD患者血浆NT-proBNP水平与LVEF、LVESD、LVEDD呈现良好的相关性(r分别为-0.63、+0.57和+0.61,P均<0.01),而血浆B igET-1水平与LVEF、LVESD、LVEDD的变化亦密切相关(r分别为-0.51、+0.46和+0.49,P均<0.01);血浆NT-proBNP和B ig ET-1水平呈正相关(r=+0.47,P<0.01)。结论:NT-proBNP和B ig ET-1可能参与了CHD及心功能损伤的病理生理过程,血浆NT-proBNP升高与B ig ET-1的变化呈正相关。更多还原

【Abstract】 Objective To investigate the changes of plasma levels of N-terminal probrain natriuretic peptide(NT-proBNP) and Big endothelin-1(Big ET-1) and their relationship with cardiac function in patients with coronary heart disease(CHD).Methods The levels of plasma NT-proBNP and Big ET-1 were measured by double antibody enzyme linked immunosorbent assay in 136 patients with CHD and 55 healthy subjects.Left ventricular ejection fraction(LVEF),left ventricular end systolic diameter(LVESD) and left ventricular end diastolic diameter(LVEDD) were determined by color Doppler ultrasonograghy in CHD patients.And the relation between plasma levels of NT-proBNP and Big ET-1.as well as the values of LVEF,LVESD and LVEDD were studied in CHD patients.Results Plasma levels of NT-proBNP and Big ET-1 were markedly increased in patients with CHD as compared with healthy subjects(P<0.01).There were also significant differences in plasma levels of NT-proBNP and Big ET-1 in subgroups with different type CHD(P<0.01).There were obvious correlation between plasma levels of NT-proBNP and Big ET-1 and the values of LVEF,LVESD and LVEDD(r=-0.63,+0.57,+0.61 and-0.51,+0.46,+0.49,P<0.01) in patients with CHD.Plasma level of NT-proBNP was apparently correlated with that of Big ET-1 in patients with CHD(r=+0.47,P<0.01).Conclusion NT-proBNP and Big ET-1 may be involved in the pathophysiological process in patients with CHD,and the elevated plasma level of NT-proBNP is positively correlated with the increase of Big ET-1 in patients with CHD.更多还原