【摘要】 【目的】了解珠海地区5岁以下儿童感染金黄色葡萄球菌(staphylococcus aureus,SAU)的耐药性。【方法】2007年1月-2009年12月从珠海市妇幼保健院4 357例5岁以下儿童送检各类标本中分离的245株SAU,K-B法进行12种抗生素的药敏试验,以美国临床实验室标准化协会(Clinical and Laboratory Standards Institute,CLSI)2009年的标准判断并采用WHONET5.4及SPSSl7.0统计软件分析结果。【结果】1岁以内婴儿占95.1%,97.1%的菌株为门诊或住院48h内送检标本中检出,89%源于痰标本,引起的疾病88.6%为肺炎。耐甲氧西林SAU(methicillin-resistant staphylococcus aureus,MRSA)的发生率为17.6%。对青霉素、克林霉素、红霉素的不敏感率分别为93.9%、51.4%、67.6%,未发现对万古霉素和利奈唑胺耐药的SAU。MRSA的耐药性高于甲氧西林敏感(methicillin sensitive staphylo-coccus aureus,MSSA)(P<0.05),而新生儿与婴幼儿感染SAU耐药性差异无统计学意义(P>0.05)。【结论】珠海地区5岁以下儿童感染的SAU中MRSA检出率不高。除青霉素、克林霉素、红霉素外,SAU对其余抗生素的耐药率不高,苯唑西林仍是治疗该地区SAU引起儿童感染的价廉而有效的药物。更多还原

【Abstract】 【Objective】 To investigate the drug-resistance of staphylococcus aureus(SAU) isolated from children under 5-year in Zhuhai area. 【Methods】 245 stains of SAU were isolated from 4 357 cases under 5-year in the Zhuhai Municipal Maternity and Child Health Care Hospital since January 2007 to December 2009.Kurby-Bauer method was used to analyze antimicrobial susceptibility of above-mentioned strains against 12 antimicrobial agents.Results were evaluated according to Clinical and Laboratory Standards Institute(CLSI) of that year.The data was statistic analysis by WHONET 5.4 and SPSS 17.0. 【Results】 95.1% of the cases were under 1-year.97.1% strains were isolated from the specimens of the outpatients and in-patients within 48 h of hospitalization.The majority of the specimens was sputum(89%) and pneumonia was the main disease among the cases(88.6%).The prevalence of the methicillin-resistant staphylococcus aureus(MRSA) was 17.6%.The rates of resistance to penicillin,clindamycin and erythromycin were 93.9%,51.4%,67.6% respectively.All were sensitive to vancomycin and linezolid.The drug-resistance of MRSA was higher than methicillin sensitive staphylococcus cureus(MSSA)(P<0.05).According to the drug resistance of SAU,there was no significant difference between the newborns and the infants(P>0.05). 【Conclusions】 The detection rate of MRSA is low in children under 5-year with SAU infection in Zhuhai area.The drug-resistance rate is not high in the microbial agents except Penicillin,Clindamycin and Erythromycin.Oxacillin is still a cheap and sensitive drug to cure the children with SAU infection in Zhuhai area.更多还原