【摘要】 目的:探讨替吉奥联合奥沙利铂治疗晚期胃癌的临床疗效。方法:回顾性分析2008年1月～2010年4月我院收治的89例晚期胃癌患者,随机分为观察组和对照组,观察组给予替吉奥和奥沙利铂,对照组应用紫杉醇联合顺铂治疗。比较两组临床疗效及毒副反应。结果:治疗后,观察组有效率为46.7%,临床获益率为77.8%,对照组有效率为34.1%,临床获益率为61.4%,两组比较差异具有显著性意义(P<0.05),观察组临床疗效明显优于对照组。毒副反应以周围神经毒性、消化道反应和骨髓抑制为主,主要有血细胞减少、血小板减少、恶心、呕吐、外周神经毒性、腹泻,部分出现贫血、口腔黏膜炎。观察组不良反应明显低于对照组,两组比较差异均有显著意义(P<0.05)。结论:替吉奥和奥沙利铂联合应用是治疗晚期胃癌的一种安全可靠,不良反应少,疗效显著的治疗方法,值得临床进一步推广应用。更多还原

【Abstract】 Objective:To study the clinical efficacy of TS1 combined with oxaliplatin in the treatment of advanced gastric cancer patients.Methods:89 advanced gastric cancer patients were randomly divided into two groups:the control group and observation group. The control group were treated with taxol and cisplatin.The observation group were treated with TS1 and oxaliplatin.The clinical efficacy and toxcity were compared.Results:Effective ratio of observation group was 46.7%,and the tumor response rate was 77.8%.The control group 34.1%and 61.4%,respectively.There was a significant difference between two groups(P<0.05).The major toxcity was neurosensory abnormity.nausea,vomiting and leucopenia.The adverse reaction ratio of the observation group was significant lower than the control group(P<0.05).Conclusion:TS1 combined with oxaliplatin was effective,security and tolerable in the treatment of advanced gastric cancer patients.更多还原