急性百草枯中毒20例临床分析

【摘要】 目的探讨急性百草枯中毒的发病机制、临床表现、救治方法及预后因素。方法对20例急性百草枯中毒住院患者的临床资料进行回顾性分析。结果死亡16例,死亡率80%,其中15例死于多脏器功能衰竭。可有局部刺激症状及肺、肝、肾、心、神经系统、血液系统损害。死亡率随服毒量增大而增加,服毒量>50ml者8例全部死亡,白细胞>200×109/L者10例,低血压及昏迷患者全部死亡。12例行血液灌流,死亡9例,死亡率75%。结论急性百草枯中毒可导致多脏器功能衰竭,死亡率高。早期洗胃,及早进行血液灌流,大剂量糖皮质激素、免疫抑制剂的应用有助于提高抢救率。更多还原

【Abstract】 Objective To investigate the pathogenesis,clinical presentations and prognostic factors of acute paraquat intoxication.Methods A retrospective analysis was conducted on the clinical data of the admitted 20 patients with acute paraquat intoxication.Results Of the total number,16 cases died,with a mortality of 80%,with 15 died of MODS,The complications occurring in cases included local irritation as well as lung,hepatic,renal,cardiac,nervous system and blood system function impairment.Mortality augmented with the increasing intake of the poison.8 cases that took more than 50ml,10 cases with WBC,200×109/L,hypotension or coma all died.12 cases were treated with routine therapy and hemoperfusion,of whom there were 9 deaths,with a mortality of 75%.Conclusion Acute paraquat intoxication can cause multiple organ failure,early gastric lavage,hemoperfusion plus plasma exchange can reduce the mortality.更多还原