慢性充血性心力衰竭患者血清ACT-A水平

【摘要】 目的检测充血性心力衰竭(CHF)患者血清激活素A(ACT-A)浓度,观察其与CHF严重程度的关系,并对其意义进行探讨。方法入选CHF患者82例和健康对照组(Con)30例,夹心酶联免疫吸附法(ELISA)检测血清ACT-A、IL-6浓度,胶乳增强免疫透射比浊法测定血清CRP浓度。结果 CHF各组ACT-A浓度显著高于Con组(125.32±66.98pg/ml),P<0.05,依次为NYHAⅡ级(411.98±175.48 pg/ml)、III级(411.98±175.48pg/ml)和IV级(411.98±175.48pg/ml)。结论 CHF患者血清中ACT-A浓度增高,且与心力衰竭严重程度相关。ACT-A可能通过调节炎症反应,参与了心力衰竭的发生发展过程。更多还原

【Abstract】 Objective To study the diference of serum activin A levels in congestive heart failure(CHF);to explore the clinical significance of changes of activin A levels in CHF patients.Methods 82 patients with congestive heart failure(CHF)and 30 controls participants(Con),were enrolled in this study.The levels of activin A,C-reactive protein and interleukin-6 were measured separately by enzyme-linked immunosorbet assay and immunoturbidimetric assay.Results Compared with healthy control subjects,patients with heart failure had significantly elevated ACT-A(468.73±235.52 pg/ml 633.72±290.90 pg/ml 695.06±283.96 pg/ml) CRP(4.49±2.12 mg/l 5.77±4.00 mg/l 6.29±4.12 mg/l) and IL-6(110.86±53.78pg/ ml 168.84±90.55 pg/ml 190.03±94.50 pg/ml) concentrations in those with NYHA classes III and IV;but with no significant differences between the two groups of patients in those with NYHA classes Ⅲ and IV.Conclusion The enhanced levels of activin A in the patients with congestive heart failure particularly high levels in patients with NYHA classes Ⅲ and IV suggests that ACT-A may involve in the process of heart failure progress as a inflammatory mediator.更多还原