三维适形放疗联合化疗治疗肺癌局部复发的疗效观察

【摘要】 目的探讨三维适形放疗联合化疗治疗方案治疗非小细胞肺癌晚期局部复发的临床近期疗效及安全性。方法 80例非小细胞肺癌晚期局部复发的患者,随机分为两组,治疗组40例,采用三维适形放疗联合化疗方案:三维适形放疗采用直线加速器、6MV-X线,CT模拟定位,放疗计量为60～70GY,6～7w完成放疗,化疗方案采用小剂量TP方案:紫杉醇30mg+顺铂30mg,每周1次,连续5～6w,同步化疗于放疗第一天开始。对照组40例,采用常规放疗联合化疗方案,放疗采用直线加速器常规外照射,化疗方案同治疗组。两组均于治疗结束后2个月评价疗效。结果 80例全部完成治疗,治疗组总有效率及1年生存率、2年生存率明显高于对照组,比较差异有统计学意义(P<0.05)。毒性反应比较差异性不显著(P>0.05)。结论三维适形放疗联合化疗治疗方案治疗非小细胞肺癌晚期局部复发有较好的近期疗效,安全性好,值得临床广泛推广应用。更多还原

【Abstract】 Objective To observe the recent clinical efficacy and safety of three-dimensional conformal radiotherapy combined with chemotherapy in the treatment of local recurrence advanced non-small cell lung cancer.Methods 80 patients with advanced non-small cell lung cancer patients were randomly divided into two groups,treatment group 40 cases,three-dimensional conformal radiotherapy combined with chemotherapy:three-dimensional conformal radiotherapy using linear accelerators,6MV-X ray,CT simulation,radiation measured as the 60～ 70GY,6～7weeks to complete radiotherapy,chemotherapy program using low-dose TP:paclitaxel and cisplatin 30mg + 30mg,1 per week for 5 to 6 weeks,concurrent chemotherapy on the first day of radiotherapy.Control group,40 patients,using conventional radiotherapy combined with chemotherapy,radiotherapy with conventional external beam linear accelerator,chemotherapy with the treatment group.Both groups were at 2 months after the end of treatment evaluated.Results 80 cases completed the treatment group and a total effective rate year survival rate,2-year survival rate was significantly higher,the difference was statistically significant(P<0.05).Toxicity difference was not significant(P>0.05).Conclusion Three-dimensional conformal radiotherapy combined with chemotherapy in the treatment of advanced non-small cell lung cancer have better short-term local recurrence of the efficacy,safety,good,worthy to be widely used.更多还原