【摘要】 目的探讨血清胸腺素β4的动态变化情况对慢性肝衰竭患者预后的判断价值。方法采用酶联免疫吸附测定法检测39例肝衰竭患者血清胸腺素β4的水平。结果 39例肝衰竭患者按照预后不同分为生存组及死亡组,生化指标TBIL(P=0.018)、凝血酶原时间国际标准化比值(international normalized ratio,INR)(P=0.000)、血清胸腺素β4(P=0.003)在2组间的差异具有统计学意义。Logistic回归分析显示,INR(P=0.033)和胸腺素β4水平(P=0.034)是影响肝衰竭患者预后的危险因素。在动态观察中,生存组患者血清胸腺素β4升高明显,INR下降明显。结论监测血清胸腺素β4和INR水平的动态变化有利于判断肝衰竭患者的预后。更多还原

【Abstract】 Objective To investigate the value of dynamic changes of serum thymosin β4 on prognosis in patients with chronic liver failure.Methods Serum thymosin β4 levels were measured by enzyme-linked immunosorbent assay in 39 patients with liver failure.Results Totally 39 patients with liver failure were divided into survivor group and non-survivor group according to their different prognosis.Before treatment,the difference of TBIL(P=0.018),international normalized ratio(INR)(P=0.000) and serum thy-mosis β4(P=0.003) between survivors and non-survivors had the statistical significance.Logistic regression analysis showed that INR(P=0.033) and serum thymosis β4(P=0.034) were the risk factors influencing the prognosis in patients with liver failure.In dynamic ob-servation,significant increase in thymosin β4 values and decrease in INR levels were found in survivor group.Conclusion Dyna-mic changes of serum thymosin β4 and INR levels can predict the prognosis in patients with liver failure.更多还原