【摘要】 目的了解HBeAg阴性慢性乙型肝炎(乙肝)及乙肝肝硬化患者的临床特点,为防治方案的制定提供依据。方法回顾性分析673例于我科住院的慢性乙肝及乙肝肝硬化患者临床资料,根据HBeAg特点分为阴性组和阳性组,分析2组患者年龄、病程、病毒学等方面的异同。结果阴性组352例,占52.3%;阳性组321例,占47.7%。阴性组患者入院时平均年龄较阳性组患者大[(51.2±13.0)、(40.8±14.1)岁,P=0.000]、HBsAg阳性持续时间长[12.0(0.5,59.0)、6.0(0.5,48.0)年,P=0.000]、血清HBVDNA载量低[1.01菖10(4<103,4.91菖108)、1.30菖10(6<103,7.11菖109)copies/ml,P=0.000],2组患者血清HBsAg定量差异无统计学意义[3685(1,9090)和3530(2,10600)U/ml,P=0.271]。阴性组并发原发性肝癌的发生率较HBeAg阳性组高(20.5%和8.7%,P=0.000)。结论在我科住院的慢性乙肝和乙肝肝硬化患者中,HBeAg阴性患者占相当的比例,HBeAg阴性患者年龄大、病史长、血清HBVDNA载量较低,并发原发性肝癌多见。更多还原

【Abstract】 Objective To investigate clinical features of patients with HBeAg-negative chronic hepatitis B(CHB) and HBV-related cirrhosis and to provide evidence for the prevention and treatment protocols.Methods A retrospective study was conducted on 673 inpatients with CHB and HBV-related cirrhosis,who were treated in our department.According to HBeAg status,all the pa-tients were divided into 2 groups,HBeAg-negative group and HBeAg-positive group.Age,duration of disease and virological features were compared between the 2 groups.Results A total of 352 patients(52.3%) were HBeAg negative and 321(47.7%) were HBeAg positive.The mean age in HBeAg-negative group was(51.2±13.0) years old,older than that in HBeAg-positive group [(40.8±14.1) years old] when they were admitted to hospital(P=0.000).The duration of HBsAg positive in HBeAg-negative group was 12.0(0.5,59.0) years,longer than that in HBeAg-positive group [6.0(0.5,48.0) years](P=0.000).The median serum HBV DNA level in HBeAg-neg-ative group was 1.01×10 4(<10 3,4.91×10 8) copies/ml,lower than that in HBeAg-positive group [1.30×10 6(<10 3,7.11×10 9) copies/ml](P=0.000).The median serum HBsAg levels were 3685(1,9090) U/ml in HBeAg-negative group and 3530(2,10 600) U/ml in HBeAg-positive group,and the difference between them was not significant(P=0.271).About 20.5% of HBeAg-negative patients developed primary liver cancer,and the proporation was higher than that of HBeAg-positive patients(8.7%)(P=0.000).Conclusions Of pa-tients with CHB and HBV-related cirrhosis admitted to our hospital,HBeAg-negative patients account for a substantial proportion.They are much older,have longer duration of disease and lower serum HBV DNA level,and more commonly develop primary liver cancer.更多还原