【摘要】 目的比较18F-脱氧葡萄糖正电子发射体层摄影术(FDG PET)/CT与MRI在鼻咽癌(NPC)颅底骨转移的检出率,为诊断NPC颅底骨侵犯提供依据。方法对25例NPC患者同时行MRI1、8F-FDG PET/CT检查,比较两种方法对颅底骨侵犯的检出率。结果 MRI检出颅底骨侵犯16例,PET/CT检出21例,肿瘤侵犯颅底骨最多的部位是枕骨斜坡(14例),其次是蝶骨体(12例),差异无统计学意义(P=0.096)。其中PET/CT检出溶骨型侵犯11例,MRI检出2例,差异有统计学意义(P=0.047)。PET/CT检出成骨型侵犯6例,MRI检出6例,差异无统计学意义(P=1.000)。PET/CT检出混合型侵犯4例,MRI检出8例,差异无统计学意义(P=0.207)。结论 PET/CT与MRI都是NPC颅底骨转移的有效检查手段,PET/CT对溶骨型侵犯的检测优于MRI,且在对放疗靶区的定位中,PET/CT优于MRI。更多还原

【Abstract】 Objective To compare 18F-fluorodeoxyglucose positron emission tomography imaging technique(positron emission tomography,PET/CT) and MRI in detecting skull base invasion of nasopharyngeal carcinoma(NPC) and to provide the evidence for diagnosis of the skull base invasion of NPC.Methods25 cases of nasopharyngeal carcinoma patients were simultaneously performed MRI,18F-FDG PET/CT examination for comparing the detection rate of skull base invasion by two methods.ResultsMRI found 16 cases of violations of the skull base,PET/CT found 21 cases of skull base invasion(the occipital slopes 14 cases),followed by the sphenoid body in 12 cases,the difference was not statistically significant(P=0.096).In the detection rate of osteolytic type violation,PET/CT detected 11 cases,MRI detected 2 cases,the difference was statistically significant(P=0.047).In the detection rate of osteogenic violation,PET/CT detected 6 cases,MRI detected 6 cases,the difference was not statistically significant(P=1.000).In the detection rate of Mixed violations,PET/CT detected 4 cases,MRI detected 8 cases,the difference was still statistically significant(P=0.207).ConclusionPET/CT and MRI are effective detection measures for skull base metastasis of,PET/CT in the detection of osteolytic type violations is better than MRI,and in the positioning of the target for radiotherapy,PET/CT is better than MRI.更多还原