【摘要】 通过表面引发连续原子转移自由基聚合的方法在玻璃表面接枝了聚(N-异丙基丙烯酰胺)-b-聚苯乙烯(PNIPAAm-b-PS)双嵌段聚合物刷。测试结果表明改性表面具有一定的浸润性温度响应性以及良好的生物学性能。与未改性的玻璃表面相比,改性后的表面具有良好的排斥血浆蛋白质的非特异性吸附能力。此外,PS链段的引入在不影响表面温敏性调控细胞黏附/脱附的条件下能够有效提高PNIPAAm改性表面在温度高于其低临界溶解温度(LCST)时对细胞的黏附能力。更多还原

【Abstract】 Poly(N-isopropylacrylamide)-block-polystyrene(PNIPAAm-b-PS) brushes were prepared via surface-initiated consecutive atom-transfer radical polymerization on initiator-immobilized glass surfaces.The characteri-zation results indicate that the modified surfaces exhibite thermo-responsivity of wettability and unique biological pro-perties.Compared with the unmodified glass surface,the PNIPAAm modified surface exhibits good non-specific protein resistance.Moreover,the introduction of PS block onto modified surfaces can enhance cell adhesion above the lower critical solution temperature(LCST) of PNIPAAm without affecting the thermo-responsive reversible adhesion and detachment of cells.更多还原