【摘要】 目的探讨内皮细胞性一氧化氮合酶(eNOS)基因内含子4上a/b基因的多态性与老年患者单纯2型糖尿病及2型糖尿病并脑梗死(cerebral infarction,CI)的关系。方法应用聚合酶链反应(PCR)技术,检测109例老年患2型糖尿病合并CI病人的基因型,并与对照组比较。结果 2型糖尿病合并CI组eNOS基因ab基因型的频率(26.61%)明显高于对照组(12.71%)(P<0.01)及2型糖尿病组(12.94%)(P<0.05),a等位基因的频率(13.30%)也明显高于对照组(6.78%)及2型糖尿病组(6.47%)(P<0.05),均有统计学意义。结论 eNOS基因ab基因型与老年人2型糖尿病合并CI有相关性,等位基因a可能是2型糖尿病合并CI的危险因素。更多还原

【Abstract】 Objective To investigate association between the a/b in intron 4 polymorphism of endothelial nitric oxide synrhase(eNOS) gene and type 2 diabetes with cerebral infarction(CI) in the aged.Methods The genotypes of 109 aged patients type 2 diabetes with CI and control group and type 2 diabetes group was performed by polymerase chain reaction(PCR).Results The ab genotype distribution frequency of eNOS gene in diabetes with CI group was higher than control group(26.61%vs12.71%)(P<0.01).higher than that of type 2 diabetes(12.94%)(P<0.05)too.The a allele frequency of eNOS gene of diabetes with CI group is significantly higher than control group(13.30%vs6.78%),is significantly higher than type 2 diabetes(6.47%)too.Statistical differences between diabetes with CI group and control group were significant(P<0.05),and between diabetes with CI group and diabetes group(P<0.05)were significant too.Conclusion There is association between ab genotype of eNOS and diabetes with CI in the aged.The eNOS a gene may be a risk factor for diabetes with CI.更多还原