Objective:To investigate significance of Nogo-A in atrophic muscle fibers in diagnosis of amyotrophic lateral sclerosis(ALS).Methods: Forty cases which were diagnosed definitely by clinical,pathological or DNA analysis were included.All of the cases underwent muscle biopsies in order to carry out Nogo-A immunostaining.Results: Nogo-A expression was detected in the atrophic muscle fibers but in either neurogenic disease or myogenic disease,the atrophic muscle fibers demonstrated expression of Nogo-A.As compa...
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