【摘要】 目的:寻找活性更好的类黄酮CDK s抑制剂。方法:利用M ann ich反应制备7个查尔酮类类黄酮。结果:目标化合物的结构经过IR、1H-NMR、ESI-MS确证,并测定了化合物对CDK1的抑制活性以及对HCT116的体外抗肿瘤活性。结论:其中有3个化合物对CDK1的抑制活性高于对照F lavop iridol,所有化合物对HCT116显示较强的抑制活性。更多还原

【Abstract】 Objective: To search flavonoids with higher CDK inhibitive ability.Methods: Chalcone route was applied to synthesize 7 chalcones.Results: The structure of target compounds was confirmed by IR,1H-NMR and ESI-MS.The CDK1 inhibitive ability and the anticancer activity against HCT116 of the compounds were determined.Conclusion: The CDK1 inhibitive ability of three compounds is higher than flavopiridol,and all compounds demonstrate higher cytotoxicity activity against HCT116.更多还原