【摘要】 目的探讨慢性HBV感染者对干扰素抗病毒疗效反应性差异与KIR基因型的相关性。方法对56名慢性HBV感染α-干扰素有效应答者(实验组)和57名慢性HBV感染干扰素无应答或部分应答者(对照组)分别进行KIR基因分型,比较2组间KIR基因型及单体型的差异。结果 AH基因型在实验组中的分布频率明显高于对照组(2χ=7.222 4,P<0.01),AF基因型及1型单体型在对照组中的分布频率明显高于实验组(2χ=10.057 5,P<0.01;2χ=16.328 3,P<0.01)。A组单体型在对照组中的分布高于实验组(2χ=5.982 8,P<0.05)。而B组则相反,在实验组中的分布高于对照组(2χ=5.983 0,P<0.05)。结论 AH基因型及B组单体型可能与α-干扰素抗病毒有效应答有关,AF基因型及1单体型和A组单体型可能与α-干扰素抗病毒疗效无应答或部分应答有关。更多还原

【Abstract】 Objective To study the correlation between killer cell immunoglobulin-like receptors(KIR)genotype diversity and the anti-HBV effection of alpha-interferon.Methods Experiment group was composed of 56 patients who perfectly response to Alpha-interferon treatment and control group was composed of 57 patients who partial /no response to alpha-interferon treatment.All cases were typed KIR genes by PCR-SSP and their KIR genotypes and haplotypes were identified.The frequencies of KIR genotypes and haplotypes were compared statistically in two groups by SPSS14.0.Results The frequencies of genotype AH were higher in experiment group than in control group(χ2=7.222 4,P<0.01),whereas,that of genotype AF and haplotype 1 were higher in control group than in experiment group(χ2=10.057 5,P<0.01;χ2=16.328 3,P<0.01),The frequencies of haplotype A were higher in control group than in experiment group(χ2=5.982 8,P<0.05,),wereas,that of haplotype B were higher in experiment group than in control group(χ2=5.983 0,P<0.05).Conclusion KIR genotype AH and haplotype B may associated with perfect reaction of Alpha-interferon′anti-HBV,while genotype AF,haplotype A and haplotype 1 may associated with part-reaction/no reaction of alpha-interferon′anti-HBV.更多还原