【摘要】 目的探讨缺氧诱导因子1 alpha(HIF-1α)和Bax蛋白在心脏性猝死(SCD)者心肌组织中的表达与相关性,并为法医学鉴定SCD提供客观依据。方法应用免疫组织化学方法,检测25例SCD者心肌组织中HIF-1α和Bax蛋白的表达,并以25例非SCD者心肌组织作为对照。结果 SCD者心肌组织HIF-1α与Bax的表达明显高于对照组(uc=6.083、5.573,P<0.01)。在SCD心肌组织中,HIF-1α表达与Bax表达呈正相关(r=0.736,P<0.01)。结论 HIF-1α与Bax表达的增高与SCD的发生有一定的相关性,HIF-1α与Bax可望作为诊断SCD较为客观的病理形态学指标。更多还原

【Abstract】 Objective To investigate the expressions of hypoxia-inducible factor-1 alpha(HIF-1α) and Bcl-2 associated X protein(Bax) and their correlation in myocardium of sudden cardiac death(SCD) and provide an objective evidence for forensicidentification.Methods The expressions of HIF-1α and Bax in myocardium of 25 SCD were detected using immunohistochemical technique,and 25 of non-sudden cardiac death served as controls.Results The expressions of HIF-1α and Bax in myocardium of the SCD were significantly higher than that of the control(Uc=6.083,5.573;P<0.01),and the expressions were positively correlated(r=0.736,P<0.01).Conclusion The elevation of the expressions of HIF-1α and Bax is associated with SCD to a certain extent.The HIF-1α and Bax will hopefully become a relatively objective pathomorphologic index in the diagnosis of SCD.更多还原