【摘要】 目的:观察吉西他滨(GEM)联合顺铂(DDP)治疗晚期软组织肉瘤的临床疗效及毒副反应。方法:选取29例软组织肉瘤患者,化疗方案采用GEM 1 000 mg/m2静脉滴注,第1和第8天;DDP 30 mg/m2静脉滴注,第1～3天。观察其疗效及毒副作用。结果:完全缓解1例,部分缓解14例,无变化7例,进展者7例,总有效率75.86%。主要毒副反应为骨髓抑制及胃肠道反应,无明显的肝肾功能损害。结论:GEM联合DDP化疗方案治疗晚期软组织肉瘤有较好的疗效,且耐受性较好。更多还原

【Abstract】 Objective:To analyze the clinical efficacy of gemcitabine and cisplatin for treatment of advanced soft tissue sarcoma.Methods:Twenty-nine patients with soft tissue sarcoma hospitalized were treated with gemcitabine and cisplatin chemotherapy:gemcitabine 1 000 mg/m2 intravenous infusion,d1,8;cisplatin 30 mg/m2 intravenous infusion,d1-3.The efficacy and toxicity were observed.Results:One case was achieved complete response,14 cases were partial response,7 cases with stable disease and 7 cases with progressed disease.The total response rate was 75.86%.The main side effects were myelosuppression and gastrointestinal reactions,no significant liver and kidney damage.Conclusions:Gemcitabine and cisplatin chemotherapy in the treatment of advanced soft tissue sarcoma has the good effect,and well tolerated.更多还原