【摘要】 目的:探讨氟比洛芬酯复合曲马多术后静脉镇痛的临床效果和不良反应。方法:选择择期骨科下肢手术40例,随机分为氟比洛芬酯复合曲马多组(A组)(氟比洛芬酯100 mg+曲马多1 000 mg+昂丹司琼8 mg)和曲马多组(B组)(曲马多1 200mg+昂丹司琼8 mg);每组总量均为100 ml。镇痛模式为背景流量2 ml/h,自控剂量每次0.5 ml,锁定时间15 min。观察24 h内视觉模拟评分(VAS)、患者自控镇痛按压次数及术后镇痛的不良反应发生情况。结果:术后8 h时B组的VAS高于A组(P<0.05),而24、和24 h的VAS 2组差异均无统计学意义(P>0.05)2,组恶心、呕吐的发生率差异均无统计学意义(P>0.05),不良反应总发生率A组低于B组(P<0.05)。镇痛期间均无嗜睡、呼吸抑制及异常出血等并发症发生。结论:氟比洛芬酯复合曲马多用于骨科下肢手术后静脉镇痛效果良好,是一种安全、有效的镇痛方法。更多还原

【Abstract】 Objective:To explore the analgesic effects and side effect of intravenous postoperative anlgesia with flurbiprofen axeyil injection combined with tramadol hydrochloride. Methods:Forty cases undergoing orthopedic surgery of lower limb were randomly divided into two groups with twenty cases each:flurbiprofen axeyil injection 100 mg+tramadol hydrochloride 1 000 mg+ondansetron hydrochloride 8 mg(A group),tramadol hydrochloride 1 200 mg+ ondansetron hydrochloride 8 mg(B group).The drugs in each group were diluted to 100ml.Analgesic pattern was background flow rate 2 ml/h with 0.5 ml self-controlled dose every time.Locking time was 15 min.The VAS score,pressing times and incidence of side effects were recorded during the period of postoperative 24 hours. Results:The VAS of group B at 8 h after operation was higher than that of group A(P<0.05),while the VAS of group B at 2,4,24 h were similar as group A(P>0.05).The accidence rate of nausea,vomiting in two groups were similar(P>0.05).The total accidence rate of group A was lower than that of group B(P<0.05).No respiratory depression or abnormal bleeding occurred in two groups. Conclusions:Intravenous postoperative analgesia with flurbiprofen axeyil injection combined with tramadol hydrochloride has a better analgesic effect than tramadol hydrochloride alone and was a safe and effective therapy.更多还原