【摘要】 目的观察参地颗粒治疗脾肾亏虚证慢性肾炎(chronic glomerulonephritis,CGN)的临床疗效。方法将65例CGN脾肾亏虚证患者随机分为治疗组30例和对照组30例,并设正常对照组20例。治疗前及治疗后8周检测两组血清白介-素6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)2、4 h尿蛋白、尿红细胞(red blood cell,RBC)计数,并与正常对照组比较。结果治疗组临床总有效率、中医证候总有效率分别为86.7%、90.0%,显著高于对照组的60.0%、63.33%(P<0.05)。治疗前对照组和治疗组血清IL-6、TNF-α水平明显高于正常对照组(P<0.05),治疗后治疗组IL-6和TNF-α显著降低(P<0.01),且显著低于对照组(P<0.05,或P<0.01);治疗组中医证候积分、24 h尿蛋白、尿RBC计数显著低于对照组(P<0.05,或P<0.01)。结论降低血清IL-6和TNF-α水平,可能是参地颗粒降低脾肾亏虚证CGN患者中医证候积分,改善临床症状,降低24 h尿蛋白和尿RBC计数的机制。更多还原

【Abstract】 Objective To observe clinical effects of Shendi Granules,a traditional Chinese medicine mainly composed of Ginseng and prepared Rehmannia root,in treating chronic glomerulonephritis(CGN) of spleen-kidney deficiency syndrome.Methods Sixty cases of CGN complicated with spleen-kidney deficiency syndrome were randomly divided into treatment group(n=30) and control group(n=30),and another 20 volunteers were set as normal control group(n=20).After treatment,the compositive clinical effects and therapeutic effects of traditional Chinese medicine(TCM) syndrome were observed and compared between the control group and the treatment group.Before treatment,and 8 weeks after treatment,the levels of urinary protein during 24 h,and the counts of urinary red blood cell(RBC),and the scores of TCM syndome were observed and compared between the control group and the treatment group.The serum levels of interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) were observed and compared among the normal control group,the control group,and the treatment group.Results The total response rates for compositive clinical effects,and therapeutic effects of TCM syndrome were 86.7% and 90.0% in the treatment group,respectively,being significantly higher than 60.0% and 63.3% in the control group(P<0.05).Before treatment,the serum levels of IL-6 and TNF-α in the control group and the treatment group were significantly higher than those in the normal control group(P<0.05).Eight weeks after treatment,the serum levels of IL-6 and TNF-α in the treatment group were significantly decreased compared with those before treatment(P<0.01),and they were significantly lower than those in the control group(P<0.05,or P<0.01).After treatment,the scores of TCM syndrome,the levels of urinary protein during 24 h,and the counts of urinary RBC in treatment group were significantly lower than those in the control group(P<0.05,or P<0.01).Conclusion The decrement of serum levels of IL-6 and TNF-α by Shendi Granules maybe serve as one of the mechanisms for its decreasing the scores of TCM syndrome,the levels of urinary protein,and the counts of urinary RBC,and ameliorating clinical symptoms in patients with CGN of spleen-kidney deficiency syndrome.更多还原