【摘要】 目的探讨施普善对HSV-1感染小鼠神经细胞保护作用。方法建立HSV-1感染神经系统的小鼠模型,将模型分为未治疗和施普善治疗组,同时设正常对照组,比较各组小鼠病死率、血清NO、IL-lβ水平变化和电镜下小鼠神经细胞形态结构变化。结果施普善治疗组小鼠病死率、血清NO及IL-1β水平均比未治疗组明显降低,差异有统计学意义(P<0.01);电镜下施普善治疗组小鼠神经细胞,髓鞘病变均较轻。结论施普善可能通过降低HSV-1感染小鼠血清NO、IL-1β水平,减轻神经细胞的炎症反应及细胞因子引起的神经毒性作用,达到对神经细胞的保护作用。更多还原

【Abstract】 Objective To study Cerebrolysin protection on the mice cerebral nerve cells which were infected HSV-1.Methods The HSV-l infected rats model were built,then the rats were divided into two groups:cerebrolysin-treated group and untreated group,meanwhile the normal control group was set.The mortality rate,NO and IL-lβ levels in serum were detected,and the variations of nerve cells were examined under microscope.Results The mortality rate,NO and IL-lβ levels in blood in Cerebrolysin-treated group were obviously lower than those in untreated group(P<0.01).Nerve cells were damaged slightly and myelin sheath changed gently under microscope in Cerebrolysin-treated group.Conclusion The protective mechanism of Cerebrolysin for nerve cell can cut down NO and IL-lβlevels in serum of rats with HSV-l infection and lessen inflammatory reaction in neurocytes and the neurotoxic action caused by cytokines.更多还原