【摘要】 目的:探讨心脏移植术3个月后,影响患者环孢素A(CsA)血药浓度的因素。方法:某医院先后采用双腔静脉法进行了10例同种异体心脏移植,术后均采用CsA口服联合免疫抑制治疗。采用多元线性回归回顾性分析同一患者在不同时期的CsA剂量、膳食结构、体重变化、肝功能、合用影响CsA代谢的药物对CsA血药浓度的影响。结果:同一患者在不同时期内CsA剂量、患者饮食结构和合用药物对CsA血药浓度的影响较大。结论:心脏移植患者术后应讲究平衡饮食,不要随便更改饮食结构。合用其他药物应咨询心脏或免疫科医生并检测CsA浓度。更多还原

【Abstract】 Objective: To find the influential factor to the blood concentrations of ciclosporin A(CsA) in patients with heart transplantation.Methods: Ten patients underwent heart transplantation and immune suppression by sandimmun neural,mycophenolate mofetil and prednisone.The selected factors are dosage of CsA,dietary pattern,change of body weight,hepatic function,administration by other drugs,self-feeling healthy score,and to find out the influential factor on the blood concentration of CsA by multiple linear regression analysis.Results: Dosage of CsA,dietary pattern,self-feeling healthy score and administration by the drugs impacted the bioavailability of CsA are the risk factors disturbed the blood concentrations of CsA.Conclusion: The balanced diet is important to immunotherapy by CsA on patients with heart transplantation.Moreover,we should suggest patients to consult heart and immunologic doctors before administration by other drugs.更多还原