【摘要】 目的:探讨血清中的前列腺特异性抗原(tPSA)、游离PSA(fPSA)及f/tPSA对前列腺增生(BHP)与前列腺癌(PCA)的诊断价值。方法:采用免疫荧光法检测经病理诊断60例前列腺增生和20例前列腺癌患者血清中的特异性抗原、游离PSA,并计算f/tPSA比值。结果:血清PSA在4 ng/ml～10 ng/ml时,前列腺增生与前列腺癌组的特异性抗原含量差异无显著性(P>0.05),游离PSA、f/tPSA比值差异具有显著性(P<0.05)。结论:在前列腺增生和前列腺癌诊断灰区,tPSA作为筛选前列腺癌的临界值存在一定缺陷;联合测定tPSA、fPSAP、f/tPSA可明显提高对PCA诊断的特异性,特别是当tPSA为4.0～10.0μg/L诊断灰区时,f/t比值对诊断前列腺癌有重要的临床意义。更多还原

【Abstract】 Objective: It is to investigate the diagnosis significance of total prostate specific antigen(tPSA),free prostate specific antigen(fPSA)and f/tPSA for prostate cancer(PCA) and bisectional prostate hypertrophy(BHP) Methods: 20patients with PCa and 60 patients with benign prostatic hypertrophy(BPH) were diagnosed by pathobiology whose levelsof tPSA,andfPSA were examined in serums by Immunofluorecence assay(FIA).The results were analyzed.Results:When tPSA level isfrom 4.0-10.0μg/L in gray zone,The difference in serum tPSA between the twogroups was not significant(P>0.05),but f/t of Pca group was significantly lower than that of BPHgroup(P<0.05).Conclusion: benign prostatic hypertrophy and prostate cancer were in gray zone.It is unreasonable that tPSA is regarded as a critical value for the diagnosis of prostate carcinoma.When tPSA level is from 4.0-10.0μg/L in gray zone,f/ t ratio has a significant value for diagnosing PCA.更多还原